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Detection of Complement Series

2012-09-11 11:41

Complements detection includes CH50, C3, C4, B factor, C1 inhibitor etc. Changes of serum complement index help diagnose different types of nephritis, and also evaluate its future prognosis.

Normal index of complement C3 is 0.85-2.00g/L, while C4 is 0.12-0.4g/L. (well, different norms are obtained by various clinics or hospitals, so this is just for your reference.) Abnormal complement system contains congenital as well as acquired abnormalities.

Complement C3 is one of the most important as well as most abundant parts in complement system. Meanwhile, it is the key link of two major activation pathways. Boosted C3 can be seen as various infectious diseases, tissue injuries, acute inflammation or liver cancer etc. occurs; while decreased ones often develop in the case of nephritis induced by immune complexes, SLE, recurrent infections, hepatitis, cirrhosis, arthralgia or rash etc.

Another key complement is C4, which acts as a vital component of classical pathway of complement activation. C4 is often used for diagnosing and treating SLE or other autoimmune diseases.

The reduction of C4 can be seen as nephritis caused by immune complexes, SLE, viral infection, hepatitis and cirrhosis. Diverse infectious diseases, acute inflammation, connective tissues or multiple myelomas etc. occur when elevated C4 develops.

Determination of CH50 (Serum total complement hemolytic activity

Serum total complement hemolytic activity

Serum total complement hemolytic activity) in serum

Normal value: 50-100kU/L

Complement is characterized as heat-resisting and enzymatic activity as well as complicated haemocyanin existing in healthy fresh serum. Other than its haemocylolysis and sterilization, complement could also boost the occurrence of inflammatory response to take part in certain allergic reaction and pathological process of autoimmune disease.

The total complement index rises when patients develop obstructive jaundice, diabetes, acute rheumatic fever, dermatomyositis, thyroiditis, nodules colitis, bacteremia, acute myocardial infarction, pneumonia or tumor etc. when does it reduce? Nephritis induced by immune complexes, lupus, rheumatoid arthritis, viral hepatitis, cirrhosis, shock, allograft rejection or recurrent diarrhea etc.

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