Featured StoryAsk a Doctor

Live chat with nephrologists for a free second opinion on your specific illness condition!Ask Dr.Shan

Lower High Creatinine

High creatinine level indicates serious kidney problem, well, how to lower creatinine level in blood naturally?Read More

Advanced Medical Inspection Equipments

The accurate diagnosis can be a powerful guarantee for the kidney disease treatment While the accurate dialysis needs the support from the advanced medical inspection equipments which achieve world-class level. More Equipment

Patients Blog

It is such a place where you can share your experience, see the international news about kidney disease and find the answers to the questions bothering.


Check your Kidneys

Find a doctor

Explore treatments

Related Topic About Kidney Disease
Special Tests for Your Kidneys
Ask a Doctor

Consult or get to know Dr.Shan of the Internal Medicine / nephrology department for free >>

Most Popular Articles
Latest News
Main > Lab Tests >
Font Size A A A

T Lymphocyte Subgroup: Detection and Clinical Significance

2012-09-11 11:42

T Lymphocyte subgroup can be used to determine cellular immune function by measuring surface marker of T cells: count of T cells, classification and activation degree. Flow cytometry is one of the quickest, most accurate as well as reliable check methods for determining CD antigen.

Changes in the total number of T cells

CD3 molecule is the major index of total T cells. The increase of CD 3 and T cells can be seen in diseases such as hyperthyroidism, lymphocytic thyroiditis, myasthenia gravis or organ transplant rejection. The reduction occurs in patients with immunodeficiency disease, malignant tumor, virus infection and those who receive immunosuppressant.

The significance

1. Immunodeficiency disease

One important cause accounting for the disease is the hypofunction and count of CD8+ cells. A typical example is SLE. Patients with such disease often live with decreased percentage of CD8+cells in mononuclear cells in peripheral blood and accompanied with increased CD4+ percentage as well as elevated ratio of CD4+/CD8+.

2. Virus infection

Reduced ratio of CD4+/CD8+ is an important sign of virus infection. In patients with chicken pox, scarlatina, measles, count of CD4+ cells decreases while count of CD8+ cells increases. Other cases with similar results are recurrent infectious mononucleosis and snail fever etc.

3. Tumor

Reduction of CD3+, CD4+cell count, increase of CD8+ cell count and sharply drop in ratio of CD4+/CD8+ can be seen when tumors develop, for example, liver cancer, gastrointestinal cancer or breast cancer. Those with tumors live with a weakened immune system. By detecting abnormal changes of T Lymphocyte Subgroup, one is able to realize the immune status, instruct clinical medications and regulate one’s immune function.

4. Hematopoiesis

The abnormality of T lymphocyte subgroup is usually related with dysfunctional proliferation and differentiation of hematopoietic cell in bone marrow.

5. Kidney disease

Humoral immunity of renal immune response is commonly seen. However, the connection between kidney disease and T lymphocyte subgroup becomes a concern with further research of T lymphocyte subgroup.

Any kidney problems? Please consult our online doctor. The satisfaction of patient is as high as 93%.

What you also want to know:
How can I get this treatment ?
How can I get this treatment in my country ?
How much is this treatment ?
What is the duration if I receive this treatment in your hospital ?
How can I go to your hospital ?

Tag: Lab Tests

Pre: Detection of Complement Series

Next: Routine lab tests of kidney disease

Any questions? Fill the form below. You will surely get the free medical advice from experts within 24 hours.

Phone Number:
Disease Description:
Related Articles