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Main > Kidney Disease > Nephrotic Syndrome
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Basics of nephrotic syndrome

Nephrotic Syndrome forms due to damages of clusters of tiny blood vessels called glomeruli. Glomeruli filter blood and separate good things as well as bad ones. Healthy glomeruli prevent protein from leaking so as to maintain adequate amount of fluid in one's body. However, injured glomeruli usually fail to function well leading to the massive protein leakage called Nephrotic Syndrome.

Massive proteinuria, edema, hypoproteinemia and hyperlipidemia are four most typical symptoms.

Several causes could result in the disease, they are:

Minimal change disease

FSGS (focal segmental glomerulosclerosis)

Membranous nephropathy

Kidney disease induced by diabetes


SLE (systemic lupus erythematosus)


Who are at the highest risks of getting Nephrotic Syndrome?

Drug abuse, for example anti-inflammatory drugs or antibiotics

People with diseases causing a weak immune system, for instance, Diabetes, organ transplantation, or cancer

Certain infections such as infections of hepatitis B and C, malaria or AIDS, things of that sort

Acute glomerulonephritis

Interstit ial nephritis

Reflux nephropathy

How to prevent Nephrotic Syndrome from happening?

For those who didn't get the disease before:

To avoid any kinds of kidney diseases in your daily lives help a lot because several medical conditions result in Nephrotic Syndrome. Beyond that, situations that can contribute to kidney problems such as diabetes and high blood pressure should be avoided.

Taking moderate exercises at least five days a week, 30 minutes per time.

For people who have already gotten it, they should:

Avoid dehydration

Pay extra attention to medications you take

Say no to X-ray tests

Make certain lifestyle modifications, such as quitting smoking if you happen to be a smoker, avoid tobacco and following renal-friendly diet

What about its prognosis?

There are many factors affecting its prognosis. First one is massive albuminuria, second is other complications such as Diabetes, high blood pressure etc.

Generally speaking, infections decide the mortality rate among people with the disease. What kind of treatments also matter. Patients with minimal change nephropathy obtain a promising outlook. Well, to those with secondary Nephrotic Syndrome, its prognosis depends on one's primary disease.