Chronic Allograft Nephropathy
Polycystic Kidney Disease (PKD) is a kidney disorder passed down through families. It is characterized by numerous cysts with different sizes. There are three types of PKD: Autosomal Dominant Polycystic Kidney Disease (ADPKD), Autosomal Recessive Polycystic Kidney Disease (ARPKD) and Acquired Cystic Kidney Disease. PKD can also damage liver, pancreas and heart, brain in some rare cases.
Autosomal Dominant PKD occurs in both children and adults, but it is much more common in adults. Symptoms usually do not appear until middle age. Autosomal Recessive PKD appears in infancy or childhood. It is much less common than Autosomal Dominant PKD, but it tends to be very severe and gets worse quickly, and it usually causes death in infancy or childhood. Acquired Cystic Kidney Disease occurs in children and adults, the cysts are more likely to develop in people who are on hemodialysis or peritoneal dialysis. The risk of developing Acquired Cystic Kidney Disease increasers with the number of years people are on dialysis.
What causes Polycystic Kidney Disease (PKD)
●Congenital dysontogenesis or genic mutation
●Toxins: Toxins can damage all kinds of cells, tissues and organs. Also it is one of the main reasons causing congenital dysontogenesis and genic mutation.
●Infections: Infections can make the internal environment changes, which will create a environment for cyst genes to change. In that case, the activity of inner factor of cysts will be increased, so the growth of cysts will be speeded up. The common infections include: urinary tract infection, gastrointestinal tract infection, skin infection, upper respiratory tract infection, trauma infection and so on.
●Diet and lifestyle: Unreasonable eating habit may cause many diseases occur. Dink alcohol and smoking can speed up gene expression and the growth of cysts.
●Too much psychological pressure or bad mood: Bad mood can decrease people's immunity, in that case, the body is easy to be attacked by germs or virus.
Even though a person carries cyst gene, he may never know he is a potential PKD patient; different people have different speed of growth of cysts, which is associated with the living habit and environment. When these cysts decrease kidney function to a certain degree, dialysis or a kidney transplant will be recommended.