Chronic Allograft Nephropathy
Henoch-Schönlein Purpura Nephritis (HSPN) is a kind of immunological disease that the allergic purpura implicates the kidney. Henoch-Schönlein Purpura Nephritis is common to be seen among children and teenagers. The most common symptoms are blood in urine and proteinuria.
Pathogenesis of Henoch-Schönlein Purpura Nephritis
The pathogenesis of Henoch-Schönlein Purpura Nephritis appears to be mediated by the deposition of polymeric IgA in glomeruli. This is analogous to the same type of IgA deposits seen in systemic small vessels, primarily those of the skin and intestine. The glomerular findings can be indistinguishable from those of IgA Nephropathy.
What factors may cause Henoch-Schönlein Purpura Nephritis?
The onset of Henoch-Schönlein Purpura Nephritis is related to the hypersensitive state of the body itself, it is a immunological disease, its sensibiligen may be germ, medicines ( tetracycline, aspirin, quinindium and so on), foods with foreign protein, toxins, insect bite, injection and so on. However, most of patients have no clear allergen.
Who is easy to be affected by Henoch-Schönlein Purpura Nephritis?
Purpura Nephritis is often seen in children and teenagers, also it can occur at any ages. 50% of cases have the history of upper respiratory tract infection within 1-3 weeks before the onset. Some Nephritis symptoms appear within a week after the onset of the disease, most of the symptoms occur within eight weeks, however, some can happen after several months.
What are the general manifestations of Henoch-Schönlein Purpura Nephritis?
Before the onset of the disease, patients usually have upper respiratory tract infection. The hemorrhagic skin rashes are mottled and scattering on distal limbs, hip and hypogastrium. Nearly all the patients have skin rashes. Sometimes they are so mild that can not be found. The first manifestation of some cases can be arthralgia, abdominal pain, blood in urine, proteinuria and melena.
Generally speaking, the prognosis of children is good, However, if Henoch-Schönlein Purpura Nephritis is delayed or can not be controlled well, it still has the possibility to develop into Renal Failure.